8-ALKYL[1,2,4]TRIAZOLO[5,1-<i>b</i>]PURINES

Authors

  • К. В. Саватеев Ural Federal University named after the First President of Russia B. N. Yeltsin
  • Е. Н. Уломский Ural Federal University named after the First President of Russia B. N. Yeltsin
  • С. С. Борисов Ural Federal University named after the First President of Russia B. N. Yeltsin
  • Е. К. Воинков Ural Federal University named after the First President of Russia B. N. Yeltsin
  • В. В. Федотов Ural Federal University named after the First President of Russia B. N. Yeltsin
  • В. Л. Русинов Ural Federal University named after the First President of Russia B. N. Yeltsin

DOI:

https://doi.org/10.1007/1716

Keywords:

anomalous nucleosides, nitrogen heterocycles, purines, triazolopyrimidines, chlorodes-oxygenation, nitro group reduction

Abstract

A novel method has been developed for the synthesis of 8-alkyl[1,2,4]triazolo[5,1-b]purines from 6‑nitro[1,2,4]triazolo[1,5-a]pyrimidin-7-ones via successive phosphoryl chloride-mediated chloro-desoxygenation, aminodehalogenation, and reduction to give 7-alkylamino-6-amino[1,2,4]triazolo-[1,5‑a]pyrimidines. The latter can be cyclized in the presence of formic acid.

How to Cite
Savateev, K. V.; Ulomsky, E. N.; Borisov, S. S.; Voinkov, E. K.; Fedotov, V. V.; Rusinov, V. L. Chem. Heterocycl. Compd. 2014, 50, 880. [Khim. Geterotsikl. Soedin. 2014, 953.]

For this article in the English edition see DOI 10.1007/s10593-014-1542-z

Author Biography

Е. Н. Уломский, Ural Federal University named after the First President of Russia B. N. Yeltsin

Евгений Нарциссович Уломский

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Published

2014-07-06

Issue

No. 6 (2014)

Section

Original Papers