A SIMPLE AND EFFICIENT APPROACH TO THE SYNTHESIS OF FUROPYRAN DERIVATIVES: FOUR-COMPONENT REACTION OF ISOCYANIDES WITH ARYLIDENE-SUBSTITUTED MELDRUM’S ACID

Abstract

An four-component (3+1) reaction of an alkyl isocyanide with arylidene-substituted Meldrum's acid in CH2Cl2 at room temperature produced furo[3,4-b]pyran-5(7H)-one derivatives in good yields. The structures of the synthesized compounds were confirmed by IR, NMR spectroscopy, mass spectra, and elemental analysis.

Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (7), pp 968-973

http://link.springer.com/article/10.1007/s10593-013-1333-y