1,2,3-THIADIAZOLYL ISOCYANATES IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDS. STUDY OF THE CYTOTOXIC ACTIVITY OF <i>N</i>-(4-METHYL-1,2,3-THIADIAZOLYL-5-YL)-<i>N</i>'-(4-METHYLPHENYL)UREA

Authors

  • Т. А. Калинина Ural Federal University named after the First President of Russia B. N. Yeltsin
  • Ю. С. Шахмина Ural Federal University named after the First President of Russia B. N. Yeltsin
  • Т. В. Глухарева Ural Federal University named after the First President of Russia B. N. Yeltsin
  • Ю. Ю. Моржерин Ural Federal University named after the First President of Russia B. N. Yeltsin
  • Ж.-Д. Фан 2State Heteroorganic Chemistry Laboratory, Nankai University
  • Р. А. Борзенкова Ural Federal University named after the First President of Russia B. N. Yeltsin
  • Е. С. Сколобанова Ural Federal University named after the First President of Russia B. N. Yeltsin
  • И. С. Киселева Ural Federal University named after the First President of Russia B. N. Yeltsin

DOI:

https://doi.org/10.1007/1764

Keywords:

6-benzylaminopurine, cytokinin, isocyanates, 1, 2, 3-thiadiazole, thidiazuron, ureas

Abstract

A simple method is proposed for the synthesis of 1,2,3-thiadiazolylureas by the reaction of 1,2,3-thiadiazolyl isocyanates with primary amines. 1,2,3-Thiadiazolyl isocyanates were obtained in situ by the Curtius rearrangement of 1,2,3-thiadiazolylcarbonyl azides. Cytokinin activity was tested for N‑(4‑methyl-1,2,3-thiadiazol-5-yl)-N'-(4-methylphenyl)urea, which is an analog of thidiazuron, differing in the presence of two methyl groups in the molecule.

How to Cite
Kalinina, T. A.; Shakhmina, Yu. S.; Glukhareva, T. V.; Morzherin, Yu. Yu.; Fan, Z.-J.; Borzenkova, R. A.; Skolobanova, E. S.; Kiseleva, I. S. Chem. Heterocycl. Compd. 2014, 50, 1039. [Khim. Geterotsikl. Soedin. 2014, 1127.]

For this article in the English edition see DOI 10.1007/s10593-014-1561-9

Author Biographies

Т. А. Калинина, Ural Federal University named after the First President of Russia B. N. Yeltsin

Татьяна Андреевна Калинина

Ю. С. Шахмина, Ural Federal University named after the First President of Russia B. N. Yeltsin

Юлия Сергеевна Шахмина

Т. В. Глухарева, Ural Federal University named after the First President of Russia B. N. Yeltsin

Татьяна Владимировна Глухарева

Ю. Ю. Моржерин, Ural Federal University named after the First President of Russia B. N. Yeltsin

Юрий Юрьевич Моржерин

И. С. Киселева, Ural Federal University named after the First President of Russia B. N. Yeltsin

Ирина Сергеевна Киселева

Downloads

Published

2014-07-25

Issue

No. 7 (2014)

Section

Original Papers