4-HYDROXY-2-QUINOLONES. 173. 1-R-3-(2-DIETHYLAMINOETHYL)-1<i>H</i>-QUINAZOLINE- 2,4-DIONE HYDROCHLORIDES AS POTENTIAL LOCAL ANESTHETIC AGENTS

Authors

  • И. В. Украинец National University of Pharmacy
  • В. В. Кравцова National University of Pharmacy
  • А. А. Ткач National University of Pharmacy
  • В. И. Мамчур Dnepropetrovsk State Medical Academy
  • Е. Ю. Коваленко Dnepropetrovsk State Medical Academy

DOI:

https://doi.org/10.1007/2786

Keywords:

isatoic anhydride, local anesthetics, alkylation, 1H-quinazoline-2, 4-diones, X-ray structural analysis

Abstract

Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkylaminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4‑hydroxy-2‑quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.

How to Cite
Ukrainets, I. V.; Kravtsova, V. V.; Tkach, A. A.; Mamchur, V. I.; Kovalenko, E. Yu. Chem. Heterocycl. Compd. 2010, 46, 96. [Khim. Geterotsikl. Soedin. 2010, 113.]

For this article in the English edition see DOI 10.1007/s10593-010-0475-4

Downloads

Published

2015-11-25

Issue

No. 1 (2010)

Section

Original Papers