3-(HETARYLAMINO)- AND 3-[(HETARYLMETHYL)AMINO]ISOQUINOLIN-1(2<i>H</i>)-ONES

Authors

  • Л. М. Потиха Taras Shevchenko Kiev National University
  • Р. М. Гуцул Taras Shevchenko Kiev National University
  • В. А. Ковтуненко Taras Shevchenko Kiev National University
  • А. А. Толмачев Taras Shevchenko Kiev National University

DOI:

https://doi.org/10.1007/2949

Keywords:

amidines, 3-aminoisocarbostyryl, 2-(arylmethyl)- and 2-(hetarylmethyl)isoquinoline-1, 3(2H, 4H)-diones, 3-hetarylaminoisoquinolin-1(2H)-ones, 3-(hetarylmethyl)aminoisoquinolin-1(2H)-ones, homophthalimide, 2-(cyanomethyl)benzoic acid

Abstract

The reaction of 2-(cyanomethyl)benzoic acid with amines RNH2 (R = Ar, Het, CH2Ar, CH2Het) leads to the formation of the corresponding 3‑NHR‑isoquinolin‑1(2H)‑ones. When R = CH2Ar and CH2Het, there is a side reaction involving hydrolysis of the hydrolytically‑unstable intermediates, derivatives of 2‑(2‑amino‑2‑iminoethyl)benzoic acid, leading to 2‑R‑isoquinoline‑1,3(2H,4H)‑diones.

How to Cite
Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.; Tolmachev, A. A. Chem. Heterocycl. Compd. 2010, 46, 457. [Khim. Geterotsikl. Soedin. 2010, 575.]

For this article in the English edition see DOI 10.1007/s10593-010-0531-0

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Published

2016-01-13

Issue

No. 4 (2010)

Section

Original Papers