REACTION OF α-TETRALONE, 1<i>Н</i>-TETRAZOL-5-AMINE, AND AROMATIC ALDEHYDES UPON MICROWAVE IRRADIATION – A CONVENIENT METHOD FOR THE SYNTHESIS OF 5,6,7,12-TETRAHYDROBENZO[<i>h</i>]TETRAZOLO[5,1-<i>b</i>]QUINAZOLINES

Authors

  • Григорий П. Кантин Saint Petersburg State University, 26 Universitetsky Ave., Peterhof, Saint Petersburg 198504
  • Михаил Ю. Красавин Saint Petersburg State University, 26 Universitetsky Ave., Peterhof, Saint Petersburg 198504

DOI:

https://doi.org/10.1007/3224

Keywords:

aldehydes, tetralone, 1Н-tetrazol-5-amine, Biginelli reaction, microwave irradiation, multicomponent reactions

Abstract

A multicomponent reaction between α-tetralone, 1Н-tetrazol-5-amine, and aromatic aldehyde, occurring upon microwave irradiation in acidic medium at 130°С, led to the formation of previously unknown 7-aryl-5,6,7,12-tetrahydrobenzo[h]tetrazolо[5,1-b]quinazolines in 5–52% yields.

Authors: Grigory P. Kantin, Mikhail Yu. Krasavin

 

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Published

2016-07-18

Issue

Vol. 52 No. 11 (2016): Non-classical methods of activation in chemistry of heterocyclic compounds

Section

Original Papers