SYNTHESIS AND CYTOTOXICITY OF AMINOMETHYLSELENOPHENO[3,2-<i>b</i>]THIOPHENE SULFONAMIDES

Authors

  • Павел Арсенян Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006
  • Кира Рубина Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006
  • Илона Домрачева Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006

DOI:

https://doi.org/10.1007/3306

Keywords:

selenium, selenophene, sulfonamide, thiophene, cytotoxicity, electrophilic addition, intramolecular cyclization

Abstract

The reaction of 5-[(aminomethyl)ethynyl]thiophene-2-sulfonamides with in situ generated selenium(IV) chloride was used to synthesize  5-aminomethyl-substituted 6-chloroselenopheno[3,2-b]thiophene-2-sulfonamides. The cytotoxicity of these compounds was studied against НТ1080 (human fibrosarcoma), MH-22A (mouse hepatoma), CCL-8 (mouse sarcoma), MES-SA (human uterine sarcoma), MCF-7 (estrogen receptor-positive human breast adenocarcinoma) cell lines, as well as the normal NIH 3T3 cell line (mouse fibroblasts).

Authors: Pavel Arsenyan*, Kira Rubina, Ilona Domracheva

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Published

2016-09-09

Issue

Vol. 52 No. 8 (2016)

Section

Original Papers