PREPARATION AND BIOLOGICAL PROPERTIES OF 2-THIO-CONTAINING PYRIMIDINES AND THEIR CONDENSED ANALOGS

Authors

  • Oleksii Y. Voskoboynik Zaporozhye State Medical University
  • Oleksandra S. Kolomoets Zaporozhye State Medical University
  • Galina G. Berest Zaporozhye State Medical University
  • Inna S. Nosulenko Zaporozhye State Medical University
  • Yuliya V. Martynenko Zaporozhye State Medical University
  • Sergiy I. Kovalenko Zaporozhye State Medical University

DOI:

https://doi.org/10.1007/3647

Keywords:

condensed pyrimidines, thioxopyrimidines, biological activity, synthesis

Abstract

The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer.

Author Biographies

Oleksii Y. Voskoboynik, Zaporozhye State Medical University

Oleksii Yurievich Voskoboynik

Oleksandra S. Kolomoets, Zaporozhye State Medical University

Oleksandra Sergeevna Kolomoets

Galina G. Berest, Zaporozhye State Medical University

Galina Grigorievna Berest

Inna S. Nosulenko, Zaporozhye State Medical University

Inna Stepanovna Nosulenko

Yuliya V. Martynenko, Zaporozhye State Medical University

Yuliya Victorovna Martynenko

Sergiy I. Kovalenko, Zaporozhye State Medical University

Sergiy Ivanovich Kovalenko

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Published

2017-04-13

Issue

Vol. 53 No. 3 (2017): Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Section

Review Articles