BIGINELLI REACTION – AN EFFECTIVE METHOD FOR THE SYNTHESIS OF DIHYDROPYRIMIDINE DERIVATIVES

Авторы

  • Nataliia Simurova National University of Food Technologies 68 Volodymyrska str. Kyiv, 01601, Ukraine
  • Olena Maiboroda National University of Food Technologies 68 Volodymyrska str. Kyiv, 01601, Ukraine

DOI:

https://doi.org/10.1007/3673

Ключевые слова:

multicomponent reactions, Biginelli reaction, 3, 4-dihydropyrimidin-2(1H)-one, condensation

Аннотация

A brief review of the publications over the past 5 years devoted to the synthesis of 3,4-dihydropyrimidin-2(1H)-one or -thione derivatives using Biginelli reaction is presented. The impact of reaction conditions (solvents, catalysts, energy input) on the yield is discussed. New combinations of reagents enabling the synthesis of a wide range of 3,4-dihydropyrimidin-2(1H)-one derivatives with various functional groups are considered.

 

Биографии авторов

Nataliia Simurova, National University of Food Technologies 68 Volodymyrska str. Kyiv, 01601, Ukraine

Associate Professor at Organic Chemistry Department

Olena Maiboroda, National University of Food Technologies 68 Volodymyrska str. Kyiv, 01601, Ukraine

Associate Professor at Organic Chemistry Department

Опубликован

2017-05-11