FACILE CONSECUTIVE THREE-COMPONENT SYNTHESIS OF 3,5-DISUBSTITUTED ISOXAZOLES

Authors

  • Christina Görgen Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie
  • Thomas J. J. Müller Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie

DOI:

https://doi.org/10.1007/3677

Keywords:

alkynes, azidation, copper-free alkynylation, cyclization, isoxazoles, multicomponent reactions

Abstract

3,5-Di(hetero)aryl-substituted isoxazoles can be rapidly synthesized in a one-pot fashion by a consecutive three-component alkynylation–cyclization sequence starting from (hetero)aroyl chloride, alkynes, and sodium azide/acetic acid under copper-free palladium catalysis as exemplified by 9 different products.

 

Author Biographies

Christina Görgen, Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie

former Ph. D. student

Thomas J. J. Müller, Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie

Chair of Organic Chemistry, Director of Institute

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Published

2017-04-23

Issue

Vol. 53 No. 4 (2017): Multicomponent reactions in the synthesis of heterocycles

Section

Original Papers