SYNTHESIS AND BIOLOGICAL PROPERTIES OF 3-(DIHYDROXYBENZOYLOXY)METHYL- AND 3-(DIACETOXYBENZOYLOXY)METHYL-7α-CHLOROCEPHALOSPORANATE SULFONES

Authors

  • Н. Григан Latvian Institute of Organic Synthesis
  • Г. Вейнберг Latvian Institute of Organic Synthesis
  • И. Шестакова Latvian Institute of Organic Synthesis
  • И. Канепе Latvian Institute of Organic Synthesis
  • Э. Лукевиц Latvian Institute of Organic Synthesis

DOI:

https://doi.org/10.1007/394

Keywords:

tert-butyl esters of 3-(dihydroxybenzoyloxy)methyl-7α-chlorocephalosporanic acid sulfones, tert-butyl esters of 3-(diacetoxybenzoyloxy)methyl-7α-chlorocephalosporanic acid sulfones, tert-butyl ester of 3-(2-hydroxybenzoyloxy)methyl-7α-chlorocephalosporanic acid sulfone, elastase inhibitors

Abstract

We describe the synthesis of tert-butyl esters of 3-(2-hydroxybenzoyloxy)methyl-, 3 (dihydroxybenzoyloxy)methyl-, and 3-(diacetoxybenzoyloxy)methyl-7α-chlorocephalosporanic acid sulfones by reaction of tert-butyl ester of 3-bromomethyl-7α-chlorocephalosporanic acid sulfone with salts of hydroxy- and acetoxy-substituted benzoic acids. We have investigated the elastase-inhibiting properties of the compounds obtained and also their in vitro cytotoxic activity.

Authors: N. Grigan, G. Veinberg, I. Shestakova, I. Kanepe, and E. Lukevics.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (10), pp 1232-1236

http://link.springer.com/article/10.1023/A%3A1002885103646

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Published

2013-03-14

Issue

No. 10 (2000)

Section

Original Papers