5-ARYL-2-FURALDEHYDES IN THE SYNTHESIS OF TETRAHYDROPYRIMIDINONES BY BIGINELLI REACTION

Authors

  • Andriy R. Vakhula Ivan Franko National University of Lviv
  • Yuriy I. Horak Ivan Franko National University of Lviv
  • Roman Z. Lytvyn Ivan Franko National University of Lviv
  • Alexandra I. Lesyuk Ivan Franko National University of Lviv
  • Vasyl Kinzhybalo Institute of Low Temperature and Structure Research
  • Fedor I. Zubkov RUDN University
  • Mykola D. Obushak Ivan Franko National University of Lviv

DOI:

https://doi.org/10.1007/4124

Keywords:

5-aryl-2-furaldehydes, pyrimidine derivatives, tetrahydropyrimidines, Biginelli reaction, crystal structure, multicomponent reactions.

Abstract

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylates was obtained.

Author Biographies

Andriy R. Vakhula, Ivan Franko National University of Lviv

Yuriy I. Horak, Ivan Franko National University of Lviv

Roman Z. Lytvyn, Ivan Franko National University of Lviv

Alexandra I. Lesyuk, Ivan Franko National University of Lviv

Vasyl Kinzhybalo, Institute of Low Temperature and Structure Research

Fedor I. Zubkov, RUDN University

Mykola D. Obushak, Ivan Franko National University of Lviv

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Published

2018-06-27

Issue

Vol. 54 No. 5 (2018)

Section

Original Papers