ECO-FRIENDLY SYNTHESIS OF NOVEL THIOHYDANTOIN-TYPE SULFUR-CONTAINING IMIDAZOLINONE DERIVATIVES FROM GLYCINE ESTER

Authors

  • Mustafa Kemal Gümüş Science-Technology Research and Application Center, Artvin Coruh University
  • Yiannis Elemes Department of Chemistry, University of Ioannina

DOI:

https://doi.org/10.1007/4201

Keywords:

glycine ester, imidazolinone thiohydantoin, imidazolone, microwave irradiation, solvent-free synthesis

Abstract

Imino derivatives of glycine ester were prepared from methyl glycinate by the known procedure and then they reacted with several amines under microwave irradiation without solvent that gave the corresponding glycine amides. By the one-component cyclocondensation, the obtained amide derivatives were transformed into thiohydantoin-type imidazolinones using solvent-free microwave procedure. All imine-ester derivatives and most of the imidazolinone derivatives were synthesized for the first time. This eco-friendly protocol can provide a suitable way for synthesizing new potentially bioactive imidazolinone derivatives.

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Published

2018-03-23

Issue

Vol. 54 No. 2 (2018)

Section

Original Papers