ACHIEVEMENTS IN THE SYNTHESIS OF CYCLOOCTYNES FOR RING STRAIN-PROMOTED [3+2] AZIDE-ALKYNE CYCLOADDITION
DOI:
https://doi.org/10.1007/4488Keywords:
cyclooctynes, [3 2] azide-alkyne cycloaddition reactions, fluorescence microscopy, in situ click chemistry, SPAAC reactions, visualization of living cell.Abstract
The aim of this review is to present the entire range of cyclooctynes that are currently known in the literature. We provide a generalized and systematic overview of methods for their synthesis and consider the applications of cyclooctynes for the purposes of molecular biology and cellular engineering. The importance of cyclooctynes for [3+2] azide-alkyne cycloaddition is demonstrated, as the high reactivity of cyclooctynes allows to perform this reaction under mild conditions without a catalyst.
Authors:
Evgeny G. Chupakhin, Mikhail Yu. Krasavin
