Pd/Cu-ASSISTED C–S ACTIVATION AND N–H INSERTION: HIGHLY VERSATILE SYNTHESIS OF 2-AMINOPYRIMIDINES FROM 3,4-DIHYDROPYRIMIDINE-2(1<i>H</i>)-THIONES

Authors

  • Hina Mathur Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan
  • Mohammed Shahrukh Khan Zai Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan
  • Poonam Khandelwal Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan
  • Neetu Kumari Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan
  • Ved Prakash Verma Department of Chemistry, Banasthali University, Tonk, Newai-304022, Rajasthan
  • Dinesh Kumar Yadav Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan

DOI:

https://doi.org/10.1007/4501

Keywords:

2-aminopyrimidines, Biginelli reaction, C–S activation, N–H insertion

Abstract

A method for the synthesis of 2-aminopyrimidines from readily available 3,4-dihydropyrimidine-2(1H)-thiones via a palladium-assisted C–S activation and N–H insertion reaction is developed. The process provides an access to a variety of highly diverse 2-aryl(alkyl)aminopyrimidine adducts in good yields.

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Published

2018-05-17

Issue

Vol. 54 No. 3 (2018): Metal-catalyzed synthesis of heterocycles

Section

Original Papers