METAL-CATALYZED PRIVILEGED 2- AND 3-FUNCTIONALIZED INDOLE SYNTHESIS

Authors

  • Arun K. Sinha Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, Uttar Pradesh Academy of Scientific and Innovative Research (AcSIR), New Delhi
  • Danish Equbal Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, Uttar Pradesh
  • Mane Rajendra Uttam Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli 229010

DOI:

https://doi.org/10.1007/4503

Keywords:

bioactive indole scaffolds, functionalized indole, heterocycles, indole, C–H activation, metal catalysis

Abstract

This review summarizes the metal-catalyzed approaches for the synthesis of privileged 2- and 3-functionalized indoles via the Fischer indole synthesis, cycloaddition reaction, C–H activation reaction, and coupling reactions. Polycyclic derivatives of indole are also listed including triptamine-based pharmaceutical 5-HT1D agonist L 775,606. Some important mechanism studies are described in details in this review. The review covers literature for the last 20 years.

Author Biography

Arun K. Sinha, Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, Uttar Pradesh Academy of Scientific and Innovative Research (AcSIR), New Delhi

ak.sinha@cdri.res.in

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Published

2018-05-15

Issue

Vol. 54 No. 3 (2018): Metal-catalyzed synthesis of heterocycles

Section

Review Articles