SYNTHESIS AND FUNCTIONALIZATION OF 2-ALKYLIDENE-5-(BROMOMETHYL)-2,3-DIHYDRO-1,3-THIAZOLE DERIVATIVES
DOI:
https://doi.org/10.1007/4507Keywords:
2-alkylidene-5-(bromomethyl)-2, 3-dihydro-1, 3-thiazoles, 2-alkylidene-5-methylidene-1, 3-thiazolidin-2-ylidenes, bromination, nucleophilic substitution.Abstract
2-Alkylidene-5-methylidene-1,3-thiazolidin-2-ylidenes react with N-bromosuccinimide to form 2-alkylidene-5-(bromomethyl)-2,3-dihydro-1,3-thiazoles, the reaction of which with S,O,N-nucleophiles is used for the selective synthesis of the corresponding 5-methyl-functionalized derivatives.
Authors:
Mariia B. Litvinchuk, Anton V. Bentya,
Nataliia Yu. Slyvka, Mykhailo V. Vovk
