AN IMPROVED SYNTHESIS OF 4-CHLORO-7<i>H</i>-PYRROLO[2,3-<i>d</i>]PYRIMIDINE

Abstract

An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7H-pyrrolo[2,3-d]pyrimidine building block.