REACTION OF 4-METHYL-2-TRIFLUOROMETHYL-1,3-OXAZIN-6-ONE WITH INDOLES

Authors

  • Сергей А. Усачев Ural Federal University named after the first President of Russia B. N. Yeltsin,
  • Кристина М. Табатчикова Ural Federal University named after the first President of Russia B. N. Yeltsin,
  • Дмитрий В. Севенард Hansa Fine Chemicals GmbH, BITZ
  • Вячеслав Я. Сосновских Ural Federal University named after the first President of Russia B. N. Yeltsin,

DOI:

https://doi.org/10.1007/4709

Keywords:

indoles, 2-(indol-3-yl)-4-methyl-2-trifluoromethyl-2, 3-dihydro-1, 3-oxazin-6-ones, 1, 3-oxazin-6-one, pyrroles, nucleophilic addition.

Abstract

The addition of indoles to 4-methyl-2-trifluoromethyl-1,3-oxazin-6-one in an acidic medium proceeds at the C-2 atom and leads to 2-(indol-3-yl)-4-methyl-2-trifluoromethyl-2,3-dihydro-1,3-oxazin-6-ones in 67–83% yields. Pyrroles and N,N-dimethylaniline either do not enter into a reaction of this type or form the addition products in very low yields (6–12%).

Author Biographies

Сергей А. Усачев, Ural Federal University named after the first President of Russia B. N. Yeltsin,

Ассистент кафедры органической химии и высокомолекулярных соединений

Кристина М. Табатчикова, Ural Federal University named after the first President of Russia B. N. Yeltsin,

Студентка департамента фундаментальной и прикладной химии

Вячеслав Я. Сосновских, Ural Federal University named after the first President of Russia B. N. Yeltsin,

Заведующий кафедры органической химии и высокомолекулярных соединений

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Published

2018-10-17

Issue

Vol. 54 No. 9 (2018)

Section

Original Papers