SYNTHESIS OF <i>N</i>-SUBSTITUTED 2-AMINOMETHYL-5-METHYL-7-PHENYLOXAZOLO[5,4-<i>b</i>]PYRIDINES

Authors

  • Ирина В. Паламарчук Institute of Chemistry, University of Tyumen, 15a Perekopskaya St., Tyumen 625003, Russia
  • Мария В. Мацукевич F. M. Dostoevsky Omsk State University, 55a Mira Ave., Omsk 644077, Russia
  • Иван В. Кулаков Institute of Chemistry, University of Tyumen, 15a Perekopskaya St., Tyumen 625003, Russia
  • Тулеген М. Сейлханов Sh. Ualikhanov Kokshetau State University, 76 Abaya St., Kokshetau 020000, Kazakhstan
  • Александр С. Фисюк F. M. Dostoevsky Omsk State University, 55a Mira Ave., Omsk 644077, Russia Omsk State Technical University, 11 Mira Ave., Omsk 644050, Russia

DOI:

https://doi.org/10.1007/4899

Keywords:

2-aminomethyloxazolo[5, 4-b]pyridine derivatives, 3-amino-4-phenylpyridin-2(1Н)-one, chloroacetamide, oxazolo[5, 4-b]-pyridine, intramolecular cyclization, nucleophilic substitution.

Abstract

2-(Chloromethyl)-5-methyl-7-phenyloxazolo[5,4-b]pyridine was obtained by intramolecular cyclization based on the previously synthesized 2-chloro-N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)acetamide. The possibility of its use in the synthesis of previously unknown 2-aminomethyloxazolo[5,4-b]pyridine derivatives by nucleophilic substitution with various amines and a cyclic amide has been shown.

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Published

2019-08-14

Issue

Vol. 55 No. 8 (2019)

Section

Short Communications