[3-(DIMETHYLAMINO)-2-(TRIFLUOROMETHYL)PROP-2-EN-1-YLIDENE]DIMETHYLAZANIUM HEXAFLUOROPHOSPHATE – EFFICIENT REAGENT FOR THE FORMATION OF TRIFLUOROMETHYL-SUBSTITUTED AZAHETEROCYCLES

Authors

  • Andrey P. Mityuk Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine
  • Sergey V. Ryabukhin Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 64 Volodymyrska St., Kyiv 01601, Ukraine

DOI:

https://doi.org/10.1007/5769

Keywords:

pyrazoles, pyridines, pyrimidines, trifluorometyl, heterocyclization

Abstract

The microreview presents a comprehensive survey of application of [3-(dimethylamino)-2-(trifluoromethyl)prop-2-en-1-ylidene]dimethylazanium salts as efficient precursors for the synthesis of trifluoromethyl-substituted azaheterocycles. The current state of the art is presented by the most important recent examples (until the end of 2019).

Author Biography

Sergey V. Ryabukhin, Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 64 Volodymyrska St., Kyiv 01601, Ukraine

Professor of department of supramolecular chemistry. Institute of High Technologies.

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Published

2020-11-26

Issue

Vol. 56 No. 11 (2020)

Section

Heterocycles in Focus