SYNTHESIS OF NEW FLUORINE-CONTAINING DERIVATIVES OF QUINOXALINE 1,4-DIOXIDES AND CONDENSED SYSTEMS DERIVED FROM THEM

Abstract

The Beirut reaction of 5,6-difluorobenzofuroxan with 1,3-diketones, β-ketoesters, and amides produces 6,7-difluoroquinoxaline 1,4-dioxides. The condensation of 2-ethoxycarbonyl-6,7-difluoro-3-methylquinoxaline 1,4-dioxide is studied. Fluorinated furo[3,4-b]- and pyrrolo[3,4-b]quinoxaline 4,9-dioxides are synthesized and further functionalized by nucleophilic substitution of fluorine and reduction of the N–O bond.

Authors: O. N. Chupakhin, S. K. Kotovskaya, N. M. Perova, Z. M. Baskakova, and V. N. Charushin.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (4), pp 459-469

http://link.springer.com/article/10.1007/BF02319335