A three-component condensation of cyclic enaminones, phenylglyoxal hydrate, and ethyl cyanoacetate in EtOH gave a number of 4,5,6,7-tetrahydroindole functional derivatives. The corresponding intermediates, 2,3,4,5,6,7-hexahydroindoles, are formed under mild conditions. Under more severe conditions (heating under reflux in DMF), cleavage of the ethoxycarbonyl group takes place.
Author Biography
Александр Н. Андин, Far Eastern Federal University,
k. L Universitetsky Ave., Russky Island, Vladivostok 690922, Russia
