SYNTHESIS OF IMIDAZO[1,2-<i>a</i>]PYRAZINE AND IMIDAZO[1,2-<i>a</i>]PYRIMIDINE DERIVATIVES

Authors

  • А. В. Борисов Enamine Ltd Institute of Organic Chemistry, National Academy of Sciences of Ukraine
  • А. А. Толмачев Enamine Ltd
  • О. А. Завада National University of Pharmacy
  • И. А. Журавель National University of Pharmacy
  • С. Н. Коваленко National University of Pharmacy

DOI:

https://doi.org/10.1007/617

Keywords:

2-aminoimidazole, imidazo[1, 2-a]pyrazines, 2-a]pyrimidines, catalytic hydrogenation

Abstract

Synthetic approaches to the construction of bicyclic systems containing the imidazole nucleus have been considered. Methods for obtaining derivatives of imidazo[1,2-a]pyrazine and imidazo[1,2-a]pyrimidine have been studied, and methods have been developed for catalytic hydrogenation of these compounds. Partial reduction of the imidazole ring on imidazo[1,2-a]pyrimidine hydrogenation has been discovered for the first time.

Authors: A. V. Borisov, A. A. Tolmachev, O. A. Zavada, I. A. Zhuravel', and S. N. Kovalenko

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (5), pp 704-711

http://link.springer.com/article/10.1007/s10593-013-1301-6

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Published

2013-05-17

Issue

No. 5 (2013)

Section

Original Papers