4-HYDROXY-2-QUINOLONES. 194. 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-<i>ij</i>]QUINOLINE-2-CARBOXYLIC ACID ALKYLAMIDES. SYNTHESIS, STRUCTURE, AND BIOLOGICAL PROPERTIES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Н. Ю. Голик National University of Pharmacy, Kharkiv 61002
  • К. В. Андреева National University of Pharmacy, Kharkiv 61002
  • О. В. Горохова National University of Pharmacy, Kharkiv 61002

DOI:

https://doi.org/10.1007/6199

Keywords:

4-hydroxy-2-oxoquinoline-3-carboxylic acid alkylamides, amidation, diuretic activity, X-ray structural analysis

Abstract

Modified methods are proposed for the preparation of the ethyl ester and alkylamides of 1-hydroxy-3‑oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. A comparative analysis has been carried out of the steric structure and diuretic activity of the synthesized compounds and the previously studied, and closely structurally related, 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo-[3,2,1‑ij]quinoline-2-carboxamides.

How to Cite
I. V. Ukrainets, I. V.; Golik, N. Yu.; Andreeva,  K. V.;
Gorokhova, O. V.  Chem. Heterocycl. Compd. 2011, 46, 1459. [Khim. Geterotsikl. Soedin. 2010, 1806.]

For this article in the English edition see DOI 10.1007/s10593-011-0692-5

 

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Published

2021-03-19

Issue

No. 12 (2010)

Section

Original Papers