SYNTHESIS OF 3(5)-ARYL-5(3)-PYRAZOLYL-1,2,4-OXADIAZOLE NITRO DERIVATIVES

Authors

  • Татьяна К. Шкинева N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991
  • Ирина А. Вацадзе N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991
  • Тигран Э. Хоранян N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991
  • Димитрий Л. Липилин N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991
  • Алла Н. Пивкина N. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow 119991
  • Игорь Л. Далингер N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991

DOI:

https://doi.org/10.1007/6200

Keywords:

arylpyrazolyl-1, 2, 4-oxadiazole, nitropyrazole, 1, cyclization, nitration, nucleophilic substitution, thermal stability

Abstract

A method was developed for the synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazoles by acylation of amidoximes with acyl chlorides, followed by cyclization of pyrazolyl-O-acylamidoximes into the respective oxadiazoles. Nitration of these products was studied, in combination with nucleophilic substitution reactions in the obtained nitro derivatives.

Authors: Tatyana K. Shkineva, Irina A. Vatsadze, Tigran E. Khoranyan, Dmitry L. Lipilin, Alla N. Pivkina, Igor L. Dalinger*

Author Biography

Игорь Л. Далингер, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991

главный научный сотрудник, д.х.н.

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Published

2021-08-26

Issue

Vol. 57 No. 7/8 (2021)

Section

Original Papers