NOVEL SYNTHESIS AND CYTOTOXIC ACTIVITY OF SOME CHROMENO[3,4-<i>b</i>]PYRROL-4(3H)-ONES

Authors

  • S. S. Soman Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002
  • T. H. Thaker Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002
  • R. A. Rajput National Institute of Pharmaceutical Education and Research, Thaltej, Ahmedabad

DOI:

https://doi.org/10.1007/6210

Keywords:

benzopyrones, halo ketones, chromeno[3, 4-b]pyrrol-4(3H)-ones, cytotoxic agents

Abstract

1-Methylchromeno[3,4-b]pyrrol-4(3H)-one and 1-phenylchromeno[3,4-b]pyrrol-4(3H)-one derivatives have been synthesized by cyclization of amides obtained by condensing α-halo ketones with 3-aminochromenones, which show cytotoxic activity against lung, colon, and breast cancer cell lines.

How to Cite

Soman, S. S.; Thaker, T. H.; Rajput, R. A. Chem. Heterocycl. Compd. 2011, 46, 1514. [Khim. Geterotsikl. Soedin. 2010, 1872.]

For this article in the English edition see DOI 10.1007/s10593-011-0701-8

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Published

2021-03-23

Issue

No. 12 (2010)

Section

Original Papers