SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW 2-[(3-AMINOPROPYL)DIMETHYLSILYL]-5-TRIALKYLGERMYLFURANS

Authors

  • L. Ignatovich Latvian Institute of Organic Synthesis Riga LV-1006
  • V. Romanovs Latvian Institute of Organic Synthesis Riga LV-1006
  • I. Shestakova Latvian Institute of Organic Synthesis Riga LV-1006
  • I. Domrachova Latvian Institute of Organic Synthesis Riga LV-1006
  • J. Popelis Latvian Institute of Organic Synthesis Riga LV-1006
  • E. Lukevics Latvian Institute of Organic Synthesis Riga LV-1006

DOI:

https://doi.org/10.1007/6225

Keywords:

2-[(3-aminopropyl)dimethylsilyl]-5-triethylgermylfurans, 2-[(3-aminopropyl)dimethylsilyl]-5-trimethylgermylfurans, 2-dimethylsilyl-5-triethylgermylfuran, 2-dimethylsilyl-5-trimethylgermylfuran, cytotoxic activity, hydrosilylation, synthesis, <sup>1</sup>H, <sup>13</sup>C, <sup>29</sup>Si NMR

Abstract

New highly cytotoxic 3-aminopropyl derivatives of 2-dimethylsilyl-5-trialkylgermylfuran  (IC50 1-3 &mu;g×ml-1) have been prepared by hydrosilylation of heterocyclic N-allylamines with corresponding hydrosilane in the presence of  Speier’s catalyst. The influence of the amine structure and alkyl substituent at germanium atom on the cytotoxicity has been investigated.

How to Cite Ignatovich, L.; Romanovs, V.; Shestakova, I.; Domrachova, I.; Popelis, J.; Lukevics, E. Chem. Heterocycl. Compd. 2009, 45, 1441. [Khim. Geterotsikl. Soedin. 2010, 1791.]

For this article in the English edition see DOI 10.1007/s10593-010-0447-8



 

 

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Published

2021-03-25

Issue

No. 12 (2009)

Section

Original Papers