SELENOPHENOCHROMONES SELECTIVELY INHIBIT HUMAN LUNG CARCINOMA CELLS GROWTH

Authors

  • Jelena Vasiljeva Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006
  • Ilona Domracheva Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006
  • Pavel Arsenyan Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006

DOI:

https://doi.org/10.1007/6254

Keywords:

chromones, selenium, selenophenochromone, cytotoxicity

Abstract

Synthetic procedures for the preparation of selenophenochromones by treating ethynyl chromones with selenium halides were elaborated.
Methyl 3-bromo-2-(1-hydroxycyclohexyl)-9-oxo-9H-selenopheno[2,3-f]chromene-7-carboxylate exhibits high selective in vitro cytotoxic
activity against human lung carcinoma cells A549 and H69 up to 1.2 μM.

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Published

2021-08-26

Issue

Vol. 57 No. 7/8 (2021)

Section

Original Papers