EFFICIENT SOLID-PHASE SYNTHESIS OF ISOCYTOSINE DERIVATIVES

Authors

  • И. А. Новаков Volgograd State Technical University, Volgograd 400131
  • Б. С. Орлинсон Volgograd State Technical University, Volgograd 400131
  • Р. В. Брунилин Volgograd State Technical University, Volgograd 400131
  • М. Б. Навроцкий Volgograd State Technical University, Volgograd 400131
  • Е. А. Гордеева Volgograd State Technical University, Volgograd 400131
  • Е. Н. Савельев Volgograd State Technical University, Volgograd 400131
  • Е. Н. Герасимов Volgograd State Technical University, Volgograd 400131

DOI:

https://doi.org/10.1007/6449

Keywords:

isocytosines, "addition-elimination" mechanism, antiviral activity, solid-phase synthesis

Abstract

We have investigated the potential use of a solid-phase synthesis of novel 6-(arylmethyl)-5-methyl-isocytosine derivatives based on the immobilization of the corresponding 2-thiothymine on a Merrifield
resin, oxidation of the immobilized form to the sulfone, and aminolysis of the latter under mild conditions.

How to Cite
Novakov, I. A.; Orlinson, B. S.; Brunilin, R. V.; Nawrozkij, M. B.;  Gordeeva, E. A.; Savel'ev, E. N.; Gerasimov, E. N. Chem. Heterocycl. Compd. 2009, 45, 1365. [Khim. Geterotsikl. Soedin. 2009, 1697.]

For this article in the English edition see DOI10.1007/s10593-010-0434-0

 

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Published

2021-10-07

Issue

No. 11 (2009)

Section

Original Papers