EFFICIENT SYNTHESIS OF 2,4-DIOXOHEXAHYDRO-1,3,5-TRIAZINE O-ACETYLGLYCOSYL GLUCOSIDES AND THEIR ANTIVIRAL ACTIVITY

Authors

  • H. Chen Department of Applied Chemistry, Guangdong Ocean University, Zhanjiang 524088
  • S.-Q. Huang Department of Applied Chemistry, Guangdong Ocean University, Zhanjiang 524088
  • J.-Y. Xie Department of Applied Chemistry, Guangdong Ocean University, Zhanjiang 524088

DOI:

https://doi.org/10.1007/6619

Keywords:

O-acetylglycosyl, O-acetylglycosyl glucoside, 2, 4-dioxohexahydro-1, 3, 5-triazine, DMAP/Et3N, tobacco mosaic virus

Abstract

Four 2,4-dioxohexahydro-1,3,5-triazine O-acetylglycosyl glucosides were synthesized through glucoside formation reactions at room temperature using 4-dimethylaminopyridine as a catalyst and triethylamine as a deacidification reagent. Their structure was confirmed by IR,  1H NMR spectra, MS, and elemental analysis. The
synthesized compounds are all of  β-configuration. The results show that DMAP is an effective catalyst; the yields can reach 83.7%. The above glucosides showed an improved antiviral activity against tobacco mosaic virus.

How to Cite
Chen, H.; Huang, S.-Q.; Xie, J.-Y. Chem. Heterocycl. Compd. 2009, 45, 976. [Khim. Geterotsikl. Soedin. 2009, 1227.]

For this article in the English edition see DOI 10.1007/s10593-009-0362-z

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Published

2022-02-21

Issue

No. 8 (2009)

Section

Original Papers