SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW TRIAZINO-, TRIAZOLO-, AND PYRAZOLOPYRIDAZINE DERIVATIVES

Authors

  • F. A. Yassin Chemistry Department, Faculty of Science, Zagazig University, Zagazig

DOI:

https://doi.org/10.1007/6622

Keywords:

diethyl malonate, ethyl acetoacetate, ethylbenzoylacetate, ethyl cyanoacetate, hydrazinopyridazine, phenacyl bromide, pyrazolopyridazine, triazinopyridazine, thiazolopyridazine

Abstract

The reaction of 3-hydrazino-4,5,6-triphenylpyridazine with phenacyl bromide afforded triazolopyridazine,  while the reaction with different aldehydes gave the corresponding 3-arylidene hydrazinopyridazine derivatives which, on the reaction with Br2/Na2CO3, gave the corresponding triazinopyridazines. Also, a fusion with ethyl acetoacetate, ethyl benzoylacetate, diethyl malonate or  ethyl phenylacetoacetate gave the corresponding pyrazolo- and triazinopyridazine derivatives. The antimicrobial activity of some new compounds has been discussed.

How to Cite
Yassin, F. A. Chem. Heterocycl. Compd. 2009, 45, 997. [Khim. Geterotsikl. Soedin. 2009, 1253.]

For this article in the English edition see DOI 10.1007/s10593-009-0381-9

 

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Published

2022-02-21

Issue

No. 8 (2009)

Section

Original Papers