SYNTHESIS OF METHYL ESTERS OF 5-AROYL-6-ARYL-2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACIDS

Authors

  • В. Л. Гейн Perm State Pharmaceutical Academy, Perm 614990
  • И. В. Крылова Perm State Medicinal Academy, Perm 614000
  • Е. П. Цыплякова Perm State Pharmaceutical Academy, Perm 614990
  • А. Р. Гайфуллина Perm State Pharmaceutical Academy, Perm 614990
  • Л. И. Варкентин Perm State Pharmaceutical Academy, Perm 614990
  • М. И. Вахрин Perm State Pharmaceutical Academy, Perm 614990

DOI:

https://doi.org/10.1007/6647

Keywords:

hydrazine hydrate, 8-hydroxy-4, 5-diphenyl-3, 4-dihydropyrimido[4, 5-d]pyridazin-2(1H)-one, substituted benzaldehydes, methyl esters of 5-aroyl-6-aryl-2-oxo-1, 2, 3, 6-tetrahydropyrimidine-4-carboxylic acids, urea, esters of aroylpyruvic acids

Abstract

Methyl esters of 5-aroyl-6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acids were synthesized from three component mixtures of methyl esters  of  aroylpyruvic  acids, urea, and substituted benzaldehydes. 8-Hydroxy-4,5-diphenyl-3,4-dihydropyrimido[4,5-d]pyridazin-2(1H)-one was synthesized by  the reaction of 5-benzoyl-2-oxo-6-phenyl-1,2,3,6-tetrahydropyrimidin-4-carboxylate with hydrazine hydrate.

How to Cite
Gein, V. L.;Krylova, I. V.; Tsypliakova, E. P.; Gaifullina, A. R.; Varkentin, L. I.; Vakhrin, M. I.  Chem. Heterocycl. Compd. 2009, 45, 829. [Khim. Geterotsikl. Soedin. 2009, 1046.]

For this article in the English edition see DOI 10.1007/s10593-009-0353-0

 

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Published

2022-03-01

Issue

No. 7 (2009)

Section

Original Papers