SYNTHESIS OF THIAZOLO[3,2-<i>a</i>]PYRIMIDINES BASED ON 4-ARYL-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE(1H)-2-THIONES AND THE CRYSTAL STRUCTURE OF ETHYL 5-(2,4-DIMETHOXYPHENYL)-7-METHYL-3-OXO-3,5-DIHYDRO-2H-THIAZOLO[3,2-<i>a</i>]PYRIMIDINE-6-CARBOXYLATE

Authors

  • И. В. Кулаков Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008
  • О. А. Нуркенов Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008
  • Д. М. Турдыбеков Research and Production Center "Phytochemistry", Ministry of Education and Science of the Republic of Kazakhstan, Karaganda 100009
  • Г. М. Исабаева Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008
  • А. С. Махмутова Research and Production Center "Phytochemistry", Ministry of Education and Science of the Republic of Kazakhstan, Karaganda 100009
  • К. М. Турдыбеков Research and Production Center "Phytochemistry", Ministry of Education and Science of the Republic of Kazakhstan, Karaganda 100009

DOI:

https://doi.org/10.1007/6655

Keywords:

3, 4-dihydropyrimidine(1H)-2-thiones, 5-dihydro-2H-thiazolo[3, 2-a]pyrimidine, methyl chloroacetate, intramolecular heterocyclization, X-ray crystallography, 1H NMR spectroscopy

Abstract

Thiazolo[3,2-a]pyrimidines were obtained in good  yield by the reaction of 4-aryl-substituted 3,4-dihydropyrimidine(1H)-2-thiones and methyl chloroacetate in boiling toluene. Their structures were shown by 1H NMR spectroscopy and X-ray crystallography.

How to Cite
Kulakov, I. V.; Nurkenov, O. A.; Turdybekov, D. M.; Issabaeva, G. M.; Mahmutova, A. S.; Turdybekov, K. M.  Chem. Heterocycl. Compd. 2009, 45, 856. [Khim. Geterotsikl. Soedin. 2009, 1075.]

For this article in the English edition see DOI 10.1007/s10593-009-0346-z


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Published

2022-03-03

Issue

No. 7 (2009)

Section

Original Papers