SYNTHESIS OF 2-ALKYL-3-(INDOL-2(OR 3)-YL)-1,3-DIHYDROISOINDOL-1-ONES BY AMIDOALKYLATION

Authors

  • Н. П. Андрюхова Moscow M. V. Lomonosov State University, Moscow 119992
  • О. А. Пожарская Moscow M. V. Lomonosov State University, Moscow 119992
  • Г. А. Голубева Moscow M. V. Lomonosov State University, Moscow 119992
  • Л. А. Свиридова Moscow M. V. Lomonosov State University, Moscow 119992
  • А. В. Садовой Moscow M. V. Lomonosov State University, Moscow 119992

DOI:

https://doi.org/10.1007/6688

Keywords:

2-alkyl-3-hydroxyphthalides, 2-alkyl-3-(indol-3-yl)-1, 3-dihydroisoindol-1-ones, indoles, amidoalkylation, rotational isomerism

Abstract

2-Alkyl-3-(indol-3-yl)-1,3-dihydroisoindol-1-ones have been obtained in good yield on amidoalkylation
of indoles with 2-alkyl-3-hydroxyphthalides in chloroform at room temperature in the presence of catalytic quantities of boron trifluoride etherate. When a substituent is present at position 3 of the indole, attack is directed to position 2 of the indole nucleus.

How to Cite
Andryukhova, N. P.; Pozharskaya, O. A.; Golubeva, G. A.; Sviridova, L. A.; Sadovoy, A. V.  Chem. Heterocycl. Compd. 2009, 45, 672. [Khim. Geterotsikl. Soedin. 2009, 847.]

For this article in the English edition see DOI 10.1007/s10593-009-0333-4

 

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Published

2022-03-24

Issue

No. 6 (2009)

Section

Original Papers