SYNTHESIS AND ALKYLATION OF <i>N</i>-METHYLMORPHOLINIUM 4-ARYL-3-CYANO-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE-2-SELENOLATES

Authors

  • К. А. Фролов "ChemEx" Laboratory, Vladimir Dal' East Ukrainian National University
  • В. В. Доценко "ChemEx" Laboratory, Vladimir Dal' East Ukrainian National University
  • С. Г. Кривоколыско "ChemEx" Laboratory, Vladimir Dal' East Ukrainian National University

DOI:

https://doi.org/10.1007/669

Keywords:

cyanoselenoacetamide, N-methylmorpholinium 1, 4, 5, 6, 7, 8-hexahydroquinoline-2-selenolates, multicomponent cyclocondensation, Hantzsch synthesis

Abstract

A multicomponent reaction of cyanoselenoacetamide with aromatic aldehydes, cyclohexane-1,3-dione, and N-methylmorpholine gave N-methylmorpholinium 4-aryl-3-cyano-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-selenolates. Alkylation of the latter occurs under mild conditions with retention of the 1,4 dihydropyridine fragment to give 2-(2-R-methylseleno)-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitriles.

Authors: K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko.

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (8), pp 1146-1150

http://link.springer.com/article/10.1007/s10593-013-1356-4

 

Author Biographies

К. А. Фролов, "ChemEx" Laboratory, Vladimir Dal' East Ukrainian National University

Константин Александрович Фролов

В. В. Доценко, "ChemEx" Laboratory, Vladimir Dal' East Ukrainian National University

Виктор Викторович Доценко

С. Г. Кривоколыско, "ChemEx" Laboratory, Vladimir Dal' East Ukrainian National University

Сергей Геннадиевич Кривоколыско

Downloads

Published

2013-07-12

Issue

No. 8 (2013)

Section

Original Papers