SYNTHESIS OF NORBORNANE SERIES TETRA- AND HEXAHYDROPYRIMIDINES

Authors

  • Е. А. Шафикова Organic Chemistry Institute, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • Д. В. Петров Organic Chemistry Institute, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • Т. А. Сапожникова Organic Chemistry Institute, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • Н. Ж. Басченко Organic Chemistry Institute, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054
  • В. А. Докичев Organic Chemistry Institute, Ufa Scientific Center of the Russian Academy of Sciences, Ufa 450054

DOI:

https://doi.org/10.1007/6691

Keywords:

exo-2-amino-exo-3-aminomethylnorbornane, hexahydropyrimidines, exo-3, 5-diazatricyclo-[6.2.1.02, 7 ]undecanes, 5-diazatricyclo[6.2.1.02, 7 ]undec-3-enes, carboxylic acids, ketones, urea, tetrahydropyrimidines, analgesic activity, condensation

Abstract

Condensation of exo-2-amino-exo-3-aminomethylnorbornane with acetone, methyl cyclopropyl ketone, cyclohexanone, urea, and formic, acetic, and benzoic acids gave norbornane series tetra- and hexahydropyrimidines. It was found that 4-cyclopropyl-4-methyl-exo-3,5-diazatricyclo[6.2.1.0<sup>2,7</sup>]undecane and 4-methyl-exo-3,5-diazatricyclo[6.2.1.0<sup>2,7</sup>]undec-3-ene show analgesic activity.

How to Cite
Shafikova, E. A.; Petrov, D. V.; Sapozhnikova, T. A.; Baschenko, N. J.; Dokichev, V. A.  Chem. Heterocycl. Compd. 2009, 45, 685. [Khim. Geterotsikl. Soedin. 2009, 862.]

For this article in the English edition see DOI 10.1007/s10593-009-0328-1

 

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Published

2022-03-24

Issue

No. 6 (2009)

Section

Original Papers