SYNTHESIS OF 2-AROYL-1-HYDROXY-4,5-DIMETHYLIMIDAZOLES BY REACTION OF 3-HYDROXYAMINO-2-BUTANONE OXIME WITH ARYLGLYOXALS

Authors

  • С. А. Амитина N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090
  • А. Я. Тихонов N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090
  • И. А. Григорьев N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090
  • Ю. В. Гатилов N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090
  • Б. А. Селиванов N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090

DOI:

https://doi.org/10.1007/6692

Keywords:

arylglyoxals, 2-aroyl-1-hydroxyimidazoles, α-aroyl nitrones, hydroxylamino oxime, pyrazine 1, 4-dioxides, X-ray structural analysis

Abstract

Treatment of the acetate of 3-hydroxyamino-2-butanone oxime with arylglyoxals gives α-aroylnitrones which cyclize under acid catalyzed conditions to form principally 2-aroyl-1-hydroxy-4,5-dimethylimidazoles. An X-ray structural analysis of 2-benzoyl-1-hydroxy-4,5-dimethylimidazole has been carried out.

How to Cite
Amitina, S. A.; Tikhonov, A. Ya.; Grigor'ev, I. A.; Gatilov, Yu. V.; Selivanov, B. A.  Chem. Heterocycl. Compd. 2009, 45, 691. [Khim. Geterotsikl. Soedin. 2009, 868.]

For this article in the English edition see DOI 10.1007/s10593-009-0329-0


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Published

2022-03-24

Issue

No. 6 (2009)

Section

Original Papers