HETEROGENEOUS NANOSTRUCTURED CATALYSTS IN THE SYNTHESIS OF POLYHYDROQUINOLINES

Abstract

This microreview focuses on the main modern synthetic approaches toward polyhydroquinolines, which represent a significant group of N-heterocycles of great interest due to the wide range of their pharmacological activities. In the last five years, several strategies with heterogeneous nanostructured catalytic systems have been adapted to the Hantzsch reaction to improve the yields of polyhydroquinolines and reduce the chemical impact on the environment. Thus, we consider it necessary to compile a systematic review of the most recent data (2017–2021).