SYNTHESIS OF NOVEL [1-AZIRIDINYL(HYDROXYIMINO)METHYL]ARENES AND THEIR CYTOTOXIC ACTIVITY

Authors

  • А. Григорьева Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Йиргенсонс Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Ященко Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • В. Андрианов Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Калвиньш Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/6817

Keywords:

aziridine, amidoximes, hydroxyimidoyl chlorides, oximes, cytotoxic activity

Abstract

The synthesis has been developed for novel potential anticancer agents whose structures contain an aziridine amidoxime group. The cytotoxic activity of all of the target compounds on different cell lines are given together with the in vitro IC50 and LD50 values found. The most promising anticancer agents were found to be the methyl 4-[1-aziridinyl(hydroxyimino)methyl]benzoate, 1-aziridinyl(2-naphthyl)-methanone oxime, and 1-aziridinyl(2-quinolyl)methanone oxime.

How to Cite
Grigorjeva, A.; Jirgensons, A.; Domracheva, I.; Yashchenko, E.; Shestakova, I.; Andrianov, V.; Kalvinsh, I.  Chem. Heterocycl. Compd. 2009, 45, 161. [Khim. Geterotsikl. Soedin. 2009, 203.]

For this article in the English edition see DOI 10.1007/s10593-009-0245-3

 

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Published

2022-05-23

Issue

No. 2 (2009)

Section

Original Papers