4-HYDROXY-2-QUINOLONES. 151. REACTION OF 4-CHLORO-3-ETHOXYCARBONYL-2-OXO-1,2-DIHYDROQUINOLINES WITH <i>p</i>-TOLUENESULFONYLHYDRAZIDE

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • А. А. Ткач National University of Pharmacy, Kharkiv 61002
  • В. В. Кравцова National University of Pharmacy, Kharkiv 61002
  • А. В. Туров Taras Shevchenko Kiev National University, Kiev 01033

DOI:

https://doi.org/10.1007/6878

Keywords:

1, 5-dihydropyrazolo[4, 3-c]quinolin-4-ones, 4-chloro-2-oxo-1, 2-dihydroquinoline-3-carboxylates, p-toluenesulfonylhydrazide, alkylation, X-ray structural analysis

Abstract

The reaction of ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate with p-toluene-sulfonylhydrazide at room temperature in the system DMSO/K2CO3 gives 5-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-5H-pyrazolo[4,3-c]quinoline-3,4-dione, alkylation of which using ethyl iodide gives the 1N-substituted derivative.

How to Cite
Ukrainets, I. V.; Tkach, A. A.; Kravtsova,  V. V.; Turov, A. V.  Chem. Heterocycl. Compd. 2009, 45, 48. [Khim. Geterotsikl. Soedin. 2009, 59.]

For this article in the English edition see DOI 10.1007/s10593-009-0224-8

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Published

2022-07-06

Issue

No. 1 (2009)

Section

Original Papers