HETEROCYCLES WITH A BRIDGING NITROGEN ATOM. 19. DEVELOPMENT OF ROUTES FOR THE SYNTHESIS OF OXAZOLOISOQUINOLINIUM SALTS BASED ON PHENACYLATION OF α-METHYL-1(3)-ISOQUINOLONES

Authors

  • Е. В. Бабаев Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow 119992
  • А. А. Невская Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow 119992
  • И. В. Длинных Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow 119992
  • В. Б. Рыбаков Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow 119992

DOI:

https://doi.org/10.1007/6897

Keywords:

1-isoquinolone, isoquinol-3-one, bridging oxazoloquinolines, O, N-alkylation

Abstract

Alkylation of 3-methyl-1-isoquinolone  and  1-methyl-3-isoquinolone with phenacyl bromides proceeds regioselectively with the formation in the first case of only an N-phenacyl derivative and in the second
only the O-derivative. The 5-methyl[1,3]oxazolo[3,2-a]isoquinolinium salt has been synthesized and its reactions with ammonia, morpholine, and sodium methylate have been investigated.

How to Cite
Babaev, E. V.; Nevskaya, A. A.;Dlinnykh, I. V.; Rybakov, V. B.  Chem. Heterocycl. Compd. 2009, 45, 93. [Khim. Geterotsikl. Soedin. 2009, 110.]

For this article in the English edition see DOI 10.1007/s10593-009-0231-9

 

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Published

2022-07-14

Issue

No. 1 (2009)

Section

Original Papers