4-HYDROXY-2-QUINOLONES. 139. SYNTHESIS, STRUCTURE, AND ANTIVIRAL ACTIVITY OF N-R-AMIDES OF 2-HYDROXY-4-OXO-4H-PYRIDO[1,2-<i>a</i>]PYRIMIDINE-3-CARBOXYLIC ACIDS

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Н. Л. Березнякова National University of Pharmacy, Kharkiv 61002
  • И. А. Тугайбей Kharkiv Medical Academy of Postgraduate Education, Kharkiv 61176

DOI:

https://doi.org/10.1007/6938

Keywords:

amides, 2-hydroxy-4-oxo-4H-pyrido[1, 2-a]pyrimidines, herpes, coronavirus, antiviral activity, X-ray structural analysis

Abstract

Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.

How to Cite
Ukrainets, I. V.; Bereznyakova, N. L.; Turaibei, I. A.  Chem. Heterocycl. Compd. 2008, 44, 50. [Khim. Geterotsikl. Soedin. 2008, 61.]

For this article in the English edition see DOI 10.1007/s10593-008-0012-x


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Published

2022-08-04

Issue

No. 1 (2008)

Section

Original Papers