4-HYDROXY-2-QUINOLONES. 140. SYNTHESIS AND DIURETIC ACTIVITY OF ARYLALKYLAMIDES OF 4-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Н. Л. Березнякова National University of Pharmacy, Kharkiv 61002
  • В. А. Паршиков National University of Pharmacy, Kharkiv 61002
  • В. Н. Кравченко National University of Pharmacy, Kharkiv 61002

DOI:

https://doi.org/10.1007/6939

Keywords:

amides, 4-methyl-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid, diuretic action, X-ray structural analysis

Abstract

The interaction of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with thionyl chloride in oxygen-containing solvents leads to the formation  of a significant amount of colored side products, consequently it was proposed the reaction be carried out in carbon tetrachloride. The synthesis of a series of amides was effected by the amidation of the obtained acid chloride with appropriate primary arylalkylamines. Results are presented of a study of the effect of the synthesized compounds on the urine-excreting function of the kidney.

How to Cite
Ukrainets, I. V.; Bereznyakova, N. L.;  Parshikov, V. A.; Kravchenko, V. N.  Chem. Heterocycl. Compd. 2008, 44, 64. [Khim. Geterotsikl. Soedin. 2008, 78.]

For this article in the English edition see DOI 10.1007/s10593-008-0009-5


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Published

2022-08-04

Issue

No. 1 (2008)

Section

Original Papers