POLYFUNCTIONAL NITRILES IN THE SYNTHESIS OF DERIVATIVES OF 1,3,4-THIADIAZOLO[3,2-<i>a</i>]PYRIMIDINES

Authors

  • М. А. Куканиев V. I. Nikitin Institute of Chemistry, Tadzhikistan Academy of Sciences, Dushanbe 734063
  • М. Д. Осимов V. I. Nikitin Institute of Chemistry, Tadzhikistan Academy of Sciences, Dushanbe 734063
  • З. Г. Сангов V. I. Nikitin Institute of Chemistry, Tadzhikistan Academy of Sciences, Dushanbe 734063
  • С. С. Сафаров V. I. Nikitin Institute of Chemistry, Tadzhikistan Academy of Sciences, Dushanbe 734063
  • М. Б. Каримов V. I. Nikitin Institute of Chemistry, Tadzhikistan Academy of Sciences, Dushanbe 734063
  • Т. Р. Раджабов V. I. Nikitin Institute of Chemistry, Tadzhikistan Academy of Sciences, Dushanbe 734063

DOI:

https://doi.org/10.1007/7130

Keywords:

alkylthio(alkoxy)propionitrile, (7-methyl-5-oxo-5H-1, 3, 4-thiadiazolo[3, 2-a]pyrimidin-2-yl)acetamide, ethyl acetoacetate, 2-R-7-methyl-5-oxo-5H-1, 2-a]pyrimidine, PPA, thiosemicarbazide

Abstract

A one-pot method has been developed for the synthesis of 2-R-7-methyl-5-oxo-5H-1,3,4-thia-diazolo[3,2-a]pyrimidine by condensation of  β-alkylthio(alkoxy)propionitrile, thiosemicarbazide, and ethyl acetoacetate in PPA, and also (7-methyl-5-oxo-5H-1,3,4-thidiazolo[3,2-a]pyrimidin-2-yl)-acetamide from cyanoacetamide, thiosemicarbazide, and ethyl acetoacetate.

How to Cite
Kukaniev, M. A.; Osimov, M. D.; Sangov, Z. G.; Safarov, S. S.;  Karimov, M. B.; Radjabov, T. R.  Chem. Heterocycl. Compd. 2008, 44, 882. [Khim. Geterotsikl. Soedin. 2008, 1096.]

For this article in the English edition see DOI 10.1007/s10593-008-0125-2


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Published

2022-10-11

Issue

No. 7 (2008)

Section

Original Papers