AMINATION OF 2-CHLORO- AND 2,4-DICHLOROPYRIMIDINES BY POLYAMINES

Abstract

A study was carried out on the amination of 2-chloro- and 2,4-dichloropyrimidines by linear polyamines and oxadiamines under catalytic and noncatalytic conditions. The reaction of excess polyamine with 2-chloropyrimidine gives the corresponding 2-aminopyrimidines,  while the reaction of
polyamines with excess of 2-chloropyrimidine gives di-, tri-, and tetraarylated derivatives. The reaction of 2,4-dichloropyrimidine with diamines was studied with different ratios of the starting reagents. The ratios of the products of substitution at pyrimidine C-2 and C-4 were found.

How to Cite
Averin, A. D.; Ulanovskaya, O. A.; Beletskaya, I. P.  Chem. Heterocycl. Compd. 2008, 44, 1146. [Khim. Geterotsikl. Soedin. 2008, 1418.]

For this article in the English edition see DOI 10.1007/s10593-008-0165-7