SYNTHESIS OF NEW 1-SUBSTITUTED 4-(2-PHENYLQUINAZOLIN-4-YL)- AND 4-(2-PHENYLQUINAZOLIN-4-YLIDENE) THIOSEMICARBAZIDES

Authors

  • W. Fathalla Department of Mathematics and Physical Sciences, Faculty of Engineering Suez Canal University, Port-Said
  • P. Pazdera Centre for Syntheses at Sustainable Conditions and Their Management, Faculty of Science, Masaryk University, Brno

DOI:

https://doi.org/10.1007/7282

Keywords:

quinazoline, thiosemicarbazide, domino reaction, hydrogen bond interaction

Abstract

Two new 1-substituted 4-(2-phenylquinazolin-4-yl)- and 4-(2-phenylquinazolin-
4-ylidene) thiosemicarbazides  were formed by a multistep  domino reaction of imidoyl isothiocyanate derivative with 1,1-di-R-hydrazine in acetone solution.  Application of hydrazine hydrate under the same reaction conditions afforded 4-(2-phenylquinazoline-4(3H)-ylidene)-2-(propen-2-yl)-1-(propan-2-ylidene) thiosemicarbazide  via a six-step
triple-component domino reaction.

How to Cite
Fathalla, W.; Pazdera, P.  Chem. Heterocycl. Compd. 2008, 44, 1374. [Khim. Geterotsikl. Soedin. 2008, 1688.]

For this article in the English edition see DOI 10.1007/s10593-009-0191-0

 

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Published

2023-01-04

Issue

No. 11 (2008)

Section

Original Papers