4-HYDROXY-2-QUINOLONES. 138. SYNTHESIS AND STUDY OF STRUCTURE – BIOLOGICAL ACTIVITY RELATIONSHIPS IN A SERIES OF 1-HYDROXY-3-OXO-5,6-DIHYDRO-3H-PYRROLO[3,2,1-<i>ij</i>]QUINOLINE-2-CARBOXYLIC ACID ANILIDES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Е. В. Моспанова National University of Pharmacy, Kharkiv 61002
  • Н. Л. Березнякова National University of Pharmacy, Kharkiv 61002
  • О. И. Набока National University of Pharmacy, Kharkiv 61002

DOI:

https://doi.org/10.1007/7313

Keywords:

anilides, 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, diuretics, amidation, antitubercular activity

Abstract

Two methods are discussed and the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid anilides has been carried out. The antitubercular activity and the effect on the urinary function of the kidney have been studied for  the compounds prepared. A structure-biological activity relationship is discussed.

How to Cite
Ukrainets, I. V.; Mospanova, E. V.; N. L. Bereznyakova, N. L.; Naboka, O. I.  Chem. Heterocycl. Compd. 2007, 43, 1532. [Khim. Geterotsikl. Soedin. 2007, 1808.]

For this article in the English edition see DOI 10.1007/s10593-007-0237-0


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Published

2023-01-16

Issue

No. 12 (2007)

Section

Original Papers