SYNTHESIS AND CYTOTOXIC PROPERTIES OF 7α-CHLORO-3-METHYL-1,1-DIOXOCEPH-3-EMS, SUBSTITUTED WITH AMIDE OR KETO GROUP AT POSITION 4

Authors

  • М. Ворона Latvian Institute of Organic Synthesis, Riga, LV-1006
  • Г. Вейнберг Latvian Institute of Organic Synthesis, Riga, LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga, LV-1006
  • И. Канепе Latvian Institute of Organic Synthesis, Riga, LV-1006
  • М. Петрова Latvian Institute of Organic Synthesis, Riga, LV-1006
  • Э. Лиепиньш Latvian Institute of Organic Synthesis, Riga, LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga, LV-1006

DOI:

https://doi.org/10.1007/7318

Keywords:

amides of 7α-chloro-3-methyl-1, 1-dioxoceph-3-em-4-carboxylic acid, amides of 2-(N, N-dimethylaminomethylene)-7α-chloro-3-methyl-1, 1-dioxoceph-3-em-4-carboxylic acids, 4-aryl-7α-chloro-3-methyl-1, 1-dioxoceph-3-ems, cytotoxic activity

Abstract

7α-Chloro-3-methyl-1,1-dioxoceph-3-ems with amide or keto group at position 4 have been synthesized by structural modification of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid. Screening of these compounds for cytotoxic activity revealed compounds with specific activity against cancer cells in vitro, capable of effective inhibition of the growth of sarcoma S-180 in vivo.

How to Cite
Vorona, M.; Veinberg, G.; Shestakova, I.; Kanepe, I.; Petrova, M.;
Liepinsh, E.; Lukevics, E.  Chem. Heterocycl. Compd. 2007, 43, 1567. [Khim. Geterotsikl. Soedin. 2007, 1849.]

For this article in the English edition see DOI 10.1007/s10593-007-0242-3


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Published

2023-01-17

Issue

No. 12 (2007)

Section

Original Papers