4-HYDROXY-2-QUINOLONES. 132. SYNTHESIS, CHEMICAL, AND BIOLOGICAL PROPERTIES OF 1-R-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS 2-NITROBENZYLIDENEHYDRAZIDES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Л. В. Сидоренко National University of Pharmacy, Kharkiv 61002
  • О. С. Головченко National University of Pharmacy, Kharkiv 61002

DOI:

https://doi.org/10.1007/7342

Keywords:

hydrazides, 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, amidation, reduction, antitubercular activity

Abstract

1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding quinoline-3-carboxamides by  zinc in glacial acetic acid but in refluxing
triethylphosphite they are converted to the symmetrical N,N'-di(4-hydroxy-2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds has been carried out.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Golovchenko, O. S.  Chem. Heterocycl. Compd. 2007, 43, 1434. [Khim. Geterotsikl. Soedin. 2007, 1687.]

For this article in the English edition see DOI 10.1007/s10593-007-0221-8

 

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Published

2023-01-20

Issue

No. 11 (2007)

Section

Original Papers